Hereditary thrombophilia and fetal loss: a prospective follow-up study

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Hereditary thrombophilia and fetal loss: a prospective follow-up study.

BACKGROUND As the placental vessels are dependent on the normal balance of procoagulant and anticoagulant mechanisms, inherited thrombophilia may be associated with fetal loss. OBJECTIVES We performed a prospective study to investigate the relation between inherited thrombophilia and fetal loss, and the influence of thromboprophylaxis on pregnancy outcome. PATIENTS AND METHODS Women were en...

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Hereditary thrombophilia and recurrent pregnancy loss: a retrospective cohort study of pregnancy outcome and obstetric complications.

BACKGROUND The association among hereditary thrombophilia, recurrent pregnancy loss (RPL) and obstetric complications is yet uncertain. The objective of the study was to assess the prognostic value of the factor V Leiden (FVL) and prothrombin (PT) mutations for the subsequent chance of live birth for women with RPL. METHODS Pregnancy outcome was recorded in a retrospective cohort of 363 women...

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Hereditary thrombophilia

Thrombophilia can be defined as a predisposition to form clots inappropriately. Thrombotic events during infancy and childhood are increasingly recognized as a significant source of mortality and morbidity. The predisposition to form clots can arise from genetic factors, acquired changes in the clotting mechanism, or, more commonly, an interaction between genetic and acquired factors. Since the...

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OBJECTIVES To assess neonatal platelet counts by comparing alloimmunised pregnancies from a Norwegian screening and intervention study with subsequent pregnancies from the same women. DESIGN Prospective observational follow-up study. SETTING A university hospital. POPULATION HPA-1a immunised women from a large Norwegian screening study that gave birth to one or more children after the scr...

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ژورنال

عنوان ژورنال: Journal of Thrombosis and Haemostasis

سال: 2004

ISSN: 1538-7933,1538-7836

DOI: 10.1111/j.1538-7836.2004.00662.x